Rodinone et al [40] observeda decrease in adipogenesis with a down regulation of alladipogenic genes in animals ablated with PTP1B, and postulatedthe pivotal role of PTP1B in the development of obesity.Similarly, we have reported that the PTP1B inhibitory potential ofCGA would be the linking factor that is responsible for theobserved increase in glucose uptake and decreased adipogenesis[27]. This evidence concerns the gene PTPN1 and obesity due to melanocortin 4 receptor deficiency.