Similarly, mesalamine activates AHR, and enhances Tregs in the absence of modulation of Th1 and Th17 cells during inflammatory bowel disease, while treatment with 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ) diminishes Th17 cells but not Th1 cells in NOD mice5,10. This evidence concerns the gene AHR and inflammatory bowel disease.