We examined both male and female H304R/+ mouse cohorts in a 12 month longitudinal assessment study to determine if the mutant Dync1h1 allele causes dominant locomotor deficits similar to those exhibited by individuals with CMT2; we also assessed whether H304R/+ male mice have neuromuscular pathologies. This evidence concerns the gene DYNC1H1 and Charcot-Marie-Tooth disease type 2.