DUSP5 and neoplasm: We show that the DUSP5 promoter is methylated in both CRC cell lines and patient tumours, but in contrast to previous findings in gatric cancer, our data indicate that this epigenetic mechanism alone is insufficient to account for downregulation of DUSP5. Notably, DUSP5 promoter methylation occurs predominantly in CIMP-high CRCs, where multiple genes and loci are coordinately methylated24.