As observed in CRC cell lines, the methylation was more frequent in CIMP I/H tumours (6/14) compared to CIMP-Low (2/33) cases (<0.005, Fisher’s exact test) (Fig. 3D), however, was not associated with reduced DUSP5 mRNA levels (Fig. 3E, p = 0.189, unpaired t-test). This evidence concerns the gene DUSP5 and neoplasm.