TARDBP and amyotrophic lateral sclerosis: To test this hypothesis, we reprogrammed primary fibroblasts from ALS patients containing mutations in TDP-43 (n = 3: patient #1 carrying G287S mutation; patient #2 carrying G294V mutation and patient #3 carrying G378S mutation) to obtain iPSC lines using a protocol based on the transduction of Sendai virus (SeV) vectors containing four reprogramming factors31.