CCL2 and Increased total leukocyte count: Since age-matched Asah1P361R/P361R;MCP-1−/− mice show reduced leukocytosis and a reduction in granulocytes in the spleen, it suggests that absence of MCP-1 can slow the rate of macrophage infiltration; this also suggests, however, that the bone marrow and thymus may be more sensitive to inflammation and injury when the sphingolipid balance is perturbed.