TLR3 and rheumatoid arthritis: Strikingly, upon TLR3 stimulation, human LNSCs derived from RA-risk individuals or RA patients exhibit a lower induction of some antiviral genes, chemokines and cytokines compared with healthy controls, thus pointing towards a deregulated antiviral response of LNSCs during systemic autoimmunity already present in patients at risk for RA.