The purpose of this study was to observe the effect of UCMSC transfected by SPK1 gene on experimental autoimmune encephalomyelitis (EAE), a common animal model to study the pathogenesis and therapeutic interventions of MS, due to the recombinant adenovirus carrying SPK1 gene having already been constructed in our lab. This evidence concerns the gene SPHK1 and experimental autoimmune encephalomyelitis.