PDC and brain cancer: A growing list of structural motifs have been shown to recognize modified histones, the most common being Bromo, Chromo, Tudor, malignant brain tumour (MBT), plant homeodomain (PHD)PHD, WD40 repeat (∼40 amino acid terminating in Trp-Asp) 14-3-3, and BRCT (BRCA1 C Terminus) domains (Taverna et al. 2007).