To confirm the role of Porcn function in Evi regulation without manipulating Wnt expression, we monitored Evi in the colon cancer cell line HCT116, that depends on Wnt secretion (Voloshanenko et al, 2013) and in the melanoma cell line A375, that expresses Wnt5A and Wnt10B endogenously (Yang et al, 2012). Here, PORCN is linked to colonic neoplasm.