ZIC1 and Alzheimer disease: In our analysis, we identified one proxy SNP (dbSNP ID: rs4783244) that is considered as being AD-related by altering the binding motif of ZIC1 and perturbing the expression of the target gene CDH13. CDH13 encodes T-cadherin, a GPI-anchored protein with cell adhesion properties that is highly expressed in the brain and cardiovascular system.