Another example is SNP rs6478109 located in the promoter region of TNFSF15. This SNP may affect the binding motif of multiple transcriptional factors and lead to the dysfunction of TNFSF15. A clinical investigation has indicated that high levels of TNFSF15 were associated with increased survival rates of breast cancer patients [51, 52]. Here, TNFSF15 is linked to breast cancer.