TIMP1 and ulcer disease: Moreover, studies have shown that SJHY Formula increases the level of collagen types I and III in granulation tissue of rats on the seventh day of wound healing [22], regulating the ratio of collagen type I and III and adjusting their metabolism in wound healing fibroblasts [23], as well as regulating the expression of matrix metalloprotease-3(MMP-3) and tissue inhibitor of metalloproteinase-1(TIMP-1) in ulcer tissues of diabetic rats [24].