Gitelman et al. first described Gitelman syndrome (GS) as an autosomal recessive disorder presenting with characteristic metabolic abnormalities [1], including hypokalemia, metabolic alkalosis, hypomagnesaemia, hypocalciuria, and renin-angiotensin-aldosterone system (RAAS) activation, along with normal or low blood pressure. This evidence concerns the gene REN and Hypokalemia.