TLN-4601, a k-ras inhibitor [26], cannot prevent GBM recurrence [27], and bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, was found to be ineffective for treating GBM patients undergoing RT and TMZ in two recent randomized control trials [28, 29]. This evidence concerns the gene KRAS and glioblastoma.