The three gene pairs of the signature for colorectal cancer diagnosis consist of GPAT3 and TRIP13, PYY and CKAP2, SDCBP2 and DAP3. These genes were found in the differentially expressed genes (Student’s t-test, FDR < 0.01) detected between the 32 cancer samples and 32 normal samples in the GSE8671 dataset. This evidence concerns the gene SDCBP2 and colorectal cancer.