IFNG and infection: In our experiments, a reduction of at least 50 fold in viral titers was found in IFN-γ-treated Towne-infected cells compared to those untreated cells (compare Towne-infected U251 cells in Fig 9A and 9B), consistent with previous observations that HCMV replication and infection is inhibited in IFN-γ-treated cells [4,10,50].