These genes included extracellular matrix proteins and extracellular matrix remodeling proteins, such as Igfbp3, Mxra8, Col3a1, Col6a1, Bgn, Timp2, Ogn, Snal1, Gfpt2, Asah3l, P4ha1, Reck, Nrp1, Ltbp3, Cxcl12, Adamsts2, Ramp1, and Eno2. Some of these genes have been found to be upregulated in liver fibrosis models. The gene discussed is IGFBP3; the disease is Hepatic fibrosis.