A few transmembrane proteins were upregulated, including transmembrane protein 255B (Tmem255b), which inhibits tumor cell proliferation and tumorigenesis in human pancreatic cancer; transmembrane protein 178 (Tmem178), the function of which is unknown; and transmembrane protein with EGF-like and 2 follistatin-like domains 2 (Tmeff2), which is androgen-regulated and has anti-proliferative effects in prostate cancer cells. This evidence concerns the gene TMEFF2 and Familial prostate cancer.