These genes included extracellular matrix proteins and extracellular matrix remodeling proteins, such as Igfbp3, Mxra8, Col3a1, Col6a1, Bgn, Timp2, Ogn, Snal1, Gfpt2, Asah3l, P4ha1, Reck, Nrp1, Ltbp3, Cxcl12, Adamsts2, Ramp1, and Eno2. Some of these genes have been found to be upregulated in liver fibrosis models. This evidence concerns the gene COL6A1 and Hepatic fibrosis.