Other genes with no known functions in the liver were also discovered in the microarray analysis, including 2 homeobox genes: HOP homeobox (Hopx), the silencing of which leads to uterine endometrial cancer, and homeobox protein Hox-B2 (Hoxb2), the increased expression of which is associated with pancreatic cancer. The gene discussed is HOXB2; the disease is familial pancreatic carcinoma.