In future studies, inclusion of some additional genes such as AJUBA, HLA-A/B, NFE2L2, KRAS, FGFR2/3 and TRAF3 could improve mutation detection and better capture the mutational landscape of HPV positive tumours, as well as favour the understanding of additional cellular and molecular mechanisms involved in tumour development such as the oxidative stress pathway. This evidence concerns the gene TRAF3 and neoplasm.