On evaluating gene array analysis of nonimmunogenic AgN2a cells compared to the parent immunogenic Neuro2a cell line, we identified down-regulation of several tumor immunosuppressive pathways, including PD-L1 (3.6-fold), CD47 (3.3-fold), CD74 (6-fold), and CD40 (2.3-fold). This evidence concerns the gene CD74 and neoplasm.