CTLA4 and neoplasm: When the vaccine was combined with both CTLA-4 and PD-L1 inhibition, all mice (n = 16 in both studies) were cured of their tumors (Fig 2B, 2C and 2D) and remained tumor free for 6 months in follow-up (log-rank test for survival, p = 0.0006) (Fig 2D, right panel).