Our recent study suggests that CUL4B associates with DDB1, RBX1, and DCAF11 to form a unique CRL4BDCAF11 E3 complex in human osteosarcoma cells, and this E3 ligase can specifically target p21Cip1 for degradation, thereby regulating cell cycle progression (Chen et al., 2017). This evidence concerns the gene CUL4B and osteosarcoma.