Generally, NF‐κB is thought to be located in the cytoplasm in most healthy cell types, whereas it is translocated to the nucleus by certain stimuli and in most cancer cells (Hoesel and Schmid, 2013). In our experiments, we found that RelA, RelB, p52, and CUL4B were primarily located in the cytoplasm in hFOB1.19 cells and healthy clinical tissues (Figs S5 and S6), whereas RelA, RelB, and CUL4B were much more abundant in U2OS cells and cancerous tissues (Figs S5 and S6). This evidence concerns the gene RELB and cancer.