MKI67 and neoplasm: SEMA4D OE was sustained in vivo (Fig. 5N), and as expected, compared with D283 control tumors, D283 SEMA4D OE tumors displayed significantly less localized growth in the vermis as demonstrated by a decrease in Ki67 staining (Fig. 5O, P) as well as a significant decrease in tumor area (2.6 ± 0.6 mm2 in D283 vs. 0.1 ± 0.07 mm2 in D283 SEMA4D OE) (Fig. 5Q).