Patients from group 2 had less pulmonary hypertension [11 (24.4%) vs 16 (66.7%); P < .001], higher peak oxygen uptake (18.3 ± 6.1 vs 14.5 ± 5.5 mL/kg per min; P < .05) and lower NT‐proBNP (2426.8 ± 4247 vs 5069.7 ± 6852 pg/mL; P < .05). The gene discussed is NPPB; the disease is pulmonary hypertension.