In contrast to the c‐myc‐amplified MEB‐Med‐8A and D283 Med medulloblastoma cells, in the SHH‐TP53‐mutated medulloblastoma line Daoy, at the highest dose, the anti‐neoplastic effect of Axitinib exceeds the cytotoxic activity of GDC‐0941 and combination of the two drugs has no additional effect. This evidence concerns the gene TP53 and medulloblastoma.