AFRS also needs to be differentiated from chronic rhinosinusitis with nasal polyp (CRSwNP) where patients tend to be non-atopic Caucasians, in an older age group, with higher socioeconomic status, lower IgE levels, and lower Lund Mackay score, and generally affected by Alternaria species and Cladosporium species [57]. This evidence concerns the gene IGHE and Nasal polyposis.