Single nucleotide point mutations (SNPs) in Toll-like receptor 1 (TLR-1), Dectin-1, PLAT (plasminogen activator tissue), VEGFA (vascular endothelial growth factor A), DENND1B (DENN/MADD Domain Containing 1B), IL-1β, IL-1RN and IL-15 genes all confer putative susceptibility to CPA following genetic analysis of affected individuals and further work remains ongoing [38,39]. The gene discussed is TLR1; the disease is congenital primary aphakia.