However, while Lhc1-dependent capsular modifications lead to partial inhibition of complement and antibody deposition, these effects do not appear to synergize strongly with human complement or antibody deficiencies [145], although an ancillary role in HIV for both peripheral blood IgM memory B-cell levels and GXM-binding IgM were found to play a role in susceptibility to cryptococcosis [146]. The gene discussed is CD40LG; the disease is agammaglobulinemia.