They report that such neurons, with deletions encompassing Snord116, show reduced expression of PCSK1 (encoding prohormone covertase), which has been previously implicated in human obesity (25), and a transcription factor NHLH2, which regulates expression of the PCSK1 gene (26, 27). Here, SNORD116 is linked to obesity due to melanocortin 4 receptor deficiency.