MAP2K7 and melanoma: Small molecule inhibitors of MEK and PI3K/mTOR, known players in melanoma, have been validated in vivo as targeted drugs suppressing melanocyte hyperplasia phenotype in HRASG12V transgenic embryos.25 Moreover, a zebrafish screen of FDA-approved compounds led to the discovery of two new potential drugs cooperating with MEK inhibitors to suppress the growth of transformed melanocytes.25 Transgenic mitfa:BRAFV600E;p53−/− zebrafish embryos demonstrate a gene signature enriched for markers of multipotent neural crest cells.