MITF and melanoma: In this model, however, melanoma does not arise at a high frequency and takes several months to develop.17Instead, when HRASG12V expression is driven in melanocyte progenitor cells by the kita (c-kit in humans) promoter, melanoma occurs spontaneously by 1–3 months in ~20% of fish.18 Recently, a novel zebrafish transgenic model of uveal melanoma was created by expressing oncogenic GNAQQ209P in the melanocyte lineage using again the mitfa promoter.