MAPK8 and central nervous system cancer: Transplanted cancer cells have been shown to be capable of inducing angiogenesis, which was enhanced by TGF-β1 and inhibited by targeted drugs, such as JNK, ERK, and PI3K inhibitors.73 Another zebrafish glioma xenograft model has been used to evaluate the in vivo efficacy of a novel small molecule radiation sensitizer identified through an in vitro drug screening in human glioma cells.74 The biological behavior of glioma cancer stem cells (GSCs) has also been explored in a zebrafish xenograft model.