CD274 and cancer: Due to the milestone discovery of the role of PD-1 [27], PD-L1 [28], and CTLA-4 [29] in inhibiting carcinogenesis, the 2017 Warren Alpert Foundation Prize was awarded to Drs. T. Honjo, L. Chen, James P. Allison, and colleagues to honor their significant contributions in the field of cancer immunotherapy [29].