The Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Investigators encountered a higher expression of Interferon ɣ receptor 1 and 2 genes (IFNGR1 and IFNGR2) in peripheral blood cells among AA with RA, higher expression of IFNGR2 was associated with increased radiographic severity; the authors suggested not only a potential pathogenic role of IFN-ɣ in terms of susceptibility and aggressiveness of disease but also its utility as a biomarker for severe radiographic progression [13]. This evidence concerns the gene IFNGR1 and rheumatoid arthritis.