TP53 and diffuse large B-cell lymphoma: Leukemic presentation of DLBCL is a rare entity that often presents with significant extranodal involvement.1, 2 This patient with TP53 deletion and complex cytogenetics received R‐Hyper‐CVAD chemotherapy with twice‐weekly intrathecal (IT) therapy (alternating methotrexate and cytarabine) for two cycles.