FCGR2A and infection: “Strength of signal” can vary in response to changes in parameters such as the percentage of bound receptors (along an infection continuum where the number of pathogens follows a bell curve), the degree of pathogen opsonization, the avidity/affinity of the TLR for the pathogen-associated molecular pattern (PAMP) or FcγR for the opsonizing IgG subtype or the size of the particle or both.