Cancer cells secrete CCL5 or induce fibroblasts to secrete CCL5, which sustain the proliferation of CCR5-positive tumor cells (48); recruit T-regulatory cells and monocytes with suppressive functions; cause osteoclast activation; and favor bone metastasis, neo-angiogenesis, and dissemination of cancer cells to distant organs (49). The gene discussed is CCR5; the disease is neoplasm.