TNF and rheumatoid arthritis: In addition, there were no significant differences between RA patients treated with biologics (n = 17, 7 patients treated with TNF inhibitors, 5 patients treated with tocilizumab, and 5 patients treated with abatacept) and RA patients treated without biologics (n = 23) regarding the M1/M2 ratio and the number of OC (Figures 4C,D).