These conditions, globally named Mendelian susceptibility to mycobacterial disease (MSMD) encompass a series of germline mutations in seven autosomal (IFNGR1, IFNGR2, IL12B, IL12RB1, STAT1, IRF8, and ISG15) and two X-linked (NEMO and CYBB) genes (6, 7). This evidence concerns the gene IL12RB1 and Mendelian susceptibility to mycobacterial diseases.