NOS2 and colorectal cancer: Detailed investigation of immune parameters revealed that iNKT cells suppressed the expression of genes associated with TH1 immunity, including IFN-γ, inducible nitric oxide synthase (iNOS), IL-12p40, T-bet, and granzyme B. A TH1-type immune response has been shown to prevent tumors in the Apcmin/+ mouse model as well as in human colorectal cancer (32–34).