CSPG4 and melanoma: The study showed that this mAb could mediate antibody-dependent cellular phagocytosis (ADCP) by human monocytes in vitro and could restrict tumor growth in vivo in a melanoma NOD-SCID-Gamma (NSG) mouse model engrafted with human immune cells (85) Interestingly, anti-CSPG4 IgG4 was demonstrated to not only lack tumor inhibition properties in vivo, but to also impair the efficacy of its IgG1 analog when administered in combination.