The study showed that this mAb could mediate antibody-dependent cellular phagocytosis (ADCP) by human monocytes in vitro and could restrict tumor growth in vivo in a melanoma NOD-SCID-Gamma (NSG) mouse model engrafted with human immune cells (85) Interestingly, anti-CSPG4 IgG4 was demonstrated to not only lack tumor inhibition properties in vivo, but to also impair the efficacy of its IgG1 analog when administered in combination. The gene discussed is CSPG4; the disease is neoplasm.