In summary, our data show the impairment of the antitumor immunity in the context of the CRC microenvironment, documented by the weakening of the effector functions of Tcc from HM to colon cancer tissues, and the increase of T lymphocytes’ subsets (Th2/Th0/Tregs/Tnull) that can promote tumor progression. Here, SFXN1 is linked to colorectal carcinoma.