Another interesting data are the presence in the cancer tissues, but not in HM, of CD4+ Tcc able to secrete IL-4 alone or in combination with IFN-γ, showing a Th2/Th0 profile; notoriously, these cells can favor cancer progression and particularly in CRC, it is reported that Th1 cell predominance is correlated with a good prognosis, whereas a high proportion of Th2 cells is correlated with a worse prognosis (43, 44). This evidence concerns the gene IFNG and cancer.