IL10 and rheumatoid arthritis: However, they also showed that IL-10 DCs induce higher numbers of IL-10+CD4+ Tregs than tolerogenic DCs generated with other protocols [involving protein kinase C inhibitor (PKCI), VitD3, dexamethasone, TGF-β, rapamycin, and peroxisome proliferator-activated receptor γ + all-trans RA] and that the Tregs induced by both IL-10 and PKCI-treated tolerogenic DCs exhibited a higher suppressive capacity compared to Tregs induced by other tolerogenic DC protocols (13, 15, 59, 84, 85).