More recently, defects in the T cell compartment including low total CD4+ T cells as well as reduced numbers of naïve CD4+ and CD8+ T cells have been associated with increased risk for specific autoimmune and lymphoproliferative complications including autoimmune cytopenias (13, 17), enteropathy (11, 17), and granulomatous-interstitial lung disease (GLILD) (15). Here, CD4 is linked to Abnormal intestine morphology.