MAPT and Alzheimer disease: Global brain UFA perturbations as well as region-specific alterations in AD patientsWithin middle frontal gyrus ↓ Linoleic acid, linolenic acid, and arachidonic acid (CN > ASYMAD > AD) and ↑ docosahexanoic acid (AD > ASYMAD > CN) may serve as regional threshold markers associated with Aβ plaques, tau tangles, and cognitive decline