Comparative in vitro binding assay of [18F]AV-1451 and [11C]PBB3 revealed that the binding of [11C]PBB3 to non-AD-type tau pathology (e.g., tufted astrocytes, astrocytic plaques, and pick bodies) was higher than that of [18F]AV-1451 (9). Here, MAPT is linked to Alzheimer disease.