It is noteworthy that diseases other than RA but combining as RA impaired cognition and high cardiovascular risk such as hypertension and diabetes were reported to induce BDNF downregulation in neurons (Pietranera et al., 2010; Franco-Robles et al., 2014), endothelial cells (Navaratna et al., 2011; Prigent-Tessier et al., 2013) or both (Monnier et al., 2017a). The gene discussed is BDNF; the disease is rheumatoid arthritis.