Previous studies show that NRF2 (Sun et al., 2016) and MT-1G (Houessinon et al., 2016), two negative regulators of ferroptosis that function by blocking GSH depletion-mediated lipid peroxidation in HCC cells, play a central role in protecting HCC cells against ferroptosis and result in sorafenib resistance. Here, NFE2L2 is linked to hepatocellular carcinoma.