NLRP3 and Sepsis: The activation of NLRP3 inflammasome has been suggested to play important roles in sepsis (Gong et al., 2015; Kim et al., 2016; Long et al., 2016; Hao et al., 2017; Lee et al., 2017), which is currently defined as life threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al., 2016).