The goal of the present study was to characterize age-related differences in cognition and brain volume between KIBRA T carriers and CC homozygotes in groups of older adults that were carefully matched on both APOE ε4 and hypertension status as well as other demographic variables, so that any differences observed would be more clearly attributable to KIBRA. We were also interested in investigating the notion of resource modulation among older adults. The gene discussed is APOE; the disease is hypertensive disorder.