NRG1 and amyotrophic lateral sclerosis: A role of NRG1 expressed in C synaptic boutons was recently suggested for ALS, since spinal MNs showed a transient increase of NRG1 during disease progression in SOD1G93A mice, whereas oculomotor MNs, which are spared in ALS, lack both C boutons and associated NRG1 (Gallart-Palau et al., 2014).