Regarding the mRNA levels of NRG1, the Type III isoform was found decreased in the ventral horn of the spinal cord from ALS human samples as well as in SOD1G93A transgenic mice in parallel with MN loss, whereas the Type I isoform was reported to increase at advanced stage of the disease in SOD1G93A mice in one study (Song et al., 2012) and to decrease in another (Lasiene et al., 2016). This evidence concerns the gene NRG1 and amyotrophic lateral sclerosis.