DUSP6 and neoplasm: While DUSP6 expression is enhanced in some kinds of cancer (melanoma and glioma cells), suggesting it may be a tumor promotor (Messina et al., 2011; Li et al., 2012), its expression is dampened in other tumors where it may exert a role as a tumor suppressor, such as pancreatic invasive cancer, primary lung cancer and ovarian cancer (Furukawa et al., 2003; Chan et al., 2008; Okudela et al., 2009).