GSK3B and Alzheimer disease: Additionally, the inhibition of GSK3β and PTEN, two molecules involved in the PIP3 pathway which have been involved in activity-dependent regulation of dendritic growth and LTD (Arendt et al., 2010; Jurado et al., 2010a; Rui et al., 2013), restored Aβ-induced AMPAR endocytosis (Rui et al., 2010) and protected synaptic function and cognition in cellular and animal models of AD (Knafo et al., 2016).