GLRA2 and microcephaly: However, deletion of Glra2 causes a moderate microcephaly in newborn mice and disrupts the functional organization of the cerebral cortex (Avila et al., 2013b; Morelli et al., 2017), which corresponds to an impaired long-term potentiation in the prefrontal cortex and deficits in object recognition memory (Pilorge et al., 2016).